The former Justice minister is set to announce her bid to clinch the top seat come the next General Election, due in 2012, at the National Museums of Kenya, Nairobi.
Ms Karua has distinguished herself as a human rights campaigner and a vocal anti-graft crusader especially in parliamentary debates.
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Ms Karua has also distanced herself from ethnic political alliances and has refused to play second fiddle to Finance minister Uhuru Kenyatta in central Kenya politics. She is on record saying that the era of political dynasty is gone and Kenyans should be allowed to elect leaders based on choice.
With the launch, the Gichugu MP will become only the third woman to vie for the presidency in Kenyan history. In 1997, Water minister Charity Ngilu and environmentalist Wangari Maathai endured unsuccessful presidential bids.